Tests aiding diagnosis of monogenic diabetes
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چکیده
منابع مشابه
A diagnosis of monogenic neonatal diabetes can improve treatment
changes in the diagnosis and treatment of diabetes presenting in the first 6 months of life. It is now known that this form of diabetes, which develops in the neonatal period, is often caused by a change in a single gene (monogenic) and is not type 1 diabetes (Slingerland and Hattersley, 2005; Edghill et al, 2006). These major changes have resulted from the identification of neonatal diabetes a...
متن کاملMonogenic Forms of Diabetes
Types 1 and 2 diabetes have multiple and complex genetic influences that interact with environmental triggers, such as viral infections or nutritional excesses, to result in their respective phenotypes: young, lean, and insulin-dependence for type 1 diabetes patients or older, overweight, and often manageable by lifestyle interventions and oral medications for type 2 diabetes patients. A small ...
متن کاملGenetic basis of monogenic diabetes
Advances in the understanding of monogenic causes of diabetes and the discovery of single-gene mutations responsible for different phenotypes have greatly increased our knowledge of β-cell physiology. Such advances have had implications for the individual patient diagnosed with the specific monogenic cause of diabetes, especially in maturity onset diabetes of the young (MODY) and neonatal diabe...
متن کاملDiagnosis of monogenic diabetes: 10‐Year experience in a large multi‐ethnic diabetes center
AIMS/INTRODUCTION Monogenic diabetes accounts for approximately 1-2% of all diabetes, and is difficult to distinguish from type 1 and type 2 diabetes. Molecular diagnosis is important, as the molecular subtype directs appropriate treatment. Patients are selected for testing according to clinical criteria, but up to 80% of monogenic diabetes in the UK has not been correctly diagnosed. We investi...
متن کاملIdentifying subtypes of monogenic diabetes
49 ISSN 1758-1907 10.2217/DMT.13.59 © 2014 Future Medicine Ltd Diabetes Manage. (2014) 4(1), 49–61 Summary Monogenic diabetes is estimated to account for 0.5–1.2% of all diabetes cases and remains underdiagnosed. It consists of a variety of subtypes associated with mutations in more than 25 genes. The main groups of monogenic diabetes include maturity-onset diabetes of the young (MODY), permane...
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ژورنال
عنوان ژورنال: Practical Diabetes
سال: 2017
ISSN: 2047-2897
DOI: 10.1002/pdi.2122